Animal models in ANCA-vasculitis

C-ANCA Positive Vasculitis in a Case of Amyloidosis

ANCA Glomerulonephritis and Vasculitis.

ANCA vasculitis has an associated autoimmune response that produces ANCAs that induce distinct pathologic lesions. Pauci-immune necrotizing and crescentic GN is a frequent component of ANCA vasculitis. ANCA vasculitis is associated with ANCA specific for myeloperoxidase (MPO-ANCA) or proteinase 3 (PR3-ANCA). A diagnosis of ANCA vasculitis should always specify the serotype as MPO-ANCA positive,...

Updates in ANCA-associated vasculitis.

Antineutrophil cytoplasm antibody (ANCA)-associated vasculitides are small-vessel vasculitides that include granulomatosis with polyangiitis (formerly Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). Renal-limited ANCA-associated vasculitides can be considered the fourth entity. Despite their rarity and still unknow...

Diagnosing ANCA-associated vasculitis in ANCA positive patients

Currently no validated diagnostic system for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is available. Therefore, diagnosing AAV is often challenging. We aimed to identify factors that lead to a clinical diagnosis AAV in ANCA positive patients in a teaching hospital in The Netherlands.In this study, all patients that tested positive for ANCA proteinase 3 (PR3) and/or ...

Treatment of ANCA – Associated Vasculitis

ANCA – associated vasculitis (AAV) encompass Wegener granulomatosus (WG), Churg Strauss syndrome (CSS) and Microscopic Polyangiitis (MPA). Granuloma formation characterizes both WG and CSS, while necrotising inflammation of middle to small arteries, pauci-immune glomerulonephritis and production of ANCA typify all three of them. Common clinical and laboratory features point towards common patho...